It depend on the mission, I’d say.

I'll definitely use mods on EX Boss Fights. No doubt on EX+ Snatcher. The only EX Boss Fight I unlocked and completed is Killing Two Birds.

I can't use mods on xbox, but I was able to beat Mafia boss and mustache girl so far.

Oh cool. Managed to complete all of Death Wish mode I think, excluding the mod death wishes.

Well, I've seen A.N.D.I before, so I know it's possible to have mods on the switch, but 1. there aren't any good mods and 2. I can't be bothered to use them.